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Thoryn Stephens28 March 2025

Have Your Best Brain ft. Thoryn Stephens

3Frameworks
13Insights

Frameworks in this episode

Insights & moments

The myth-busts, hot takes, explainers, and tools worth keeping.

Hot Take· 2

Hot Take35:30

Stephens' take on the FDA, glyphosate, and PFAS in the US food and water supply

Stephens argues the FDA and EPA have allowed harmful substances like glyphosate herbicide and PFAS ('forever chemicals') into the US food and water supply, contrasting US Kellogg's ingredients with the Canadian version of the same product. He calls it criminal what children are being exposed to, and expresses cautious optimism about regulatory change.

  • Points to Kellogg's using different ingredients in the US vs Canada
  • Calls glyphosate's presence in the food chain 'absolutely criminal'
  • Flags PFAS (polyfluoroalkyl substances) contamination in US water supplies
  • Argues western medicine and big pharma are incentivized by sickness, not prevention
  • Expresses cautious optimism about change under new regulatory leadership

It is absolutely criminal that you know these herbicides have been allowed into our food chain.

Thoryn Stephens · 36:00
#food safety#FDA#PFAS#glyphosate#regulation
Hot Take46:00

"You're going to meet your significant other at a biohacking lounge, not a nightclub"

The host and Stephens riff on biohacking becoming mainstream enough to replace nightlife as a social venue, with Stephens noting Brain One already lets users SMS their health protocol to someone they just met as a way of signaling compatibility.

  • Host predicts biohacking lounges will replace nightclubs as a place to meet people
  • Brain One already supports sharing your health protocol via SMS to a new acquaintance
  • Framed as 'productizing your health routine' for social signaling
  • Tied to the broader theme that biohacking is moving from niche to mainstream

You're not going to meet them at a nightclub... you literally just SMS them your protocol and they can see what you do.

Thoryn Stephens · 46:30
#biohacking#social trends#brain one#future predictions

Explainer· 3

Explainer02:30

What Brain One actually does, in Stephens' own words

Brain One answers the question fans ask influencers and athletes: what is their actual daily health protocol? It structures a person's routine into microhabits, nutrition, and supplementation, then closes the loop with measurement ranging from self-report all the way to advanced blood markers and integrations with hundreds of wearables.

  • Built to answer 'what does this athlete/influencer do every day'
  • Structures routines into microhabits, nutrition, and supplementation
  • API integrates with roughly 300-400 different wearables
  • Measurement spans self-report, biometrics, biomarkers, imaging, EEG, and brain-computer interfaces
  • Mission stated as reaching a billion humans through biological optimization

You know what does this athlete do on their daily basis and it does so by putting it into a structured framework.

Thoryn Stephens · 02:30
#brain one#startup#biohacking#wearables
Explainer06:00

The Lancet 2020 paper Brain One built its dementia-prevention protocol on

Stephens references a widely cited paper (originally 2017, commonly called 'Lancet 2020') built on the hypothesis that dementia is preventable through a defined set of modifiable behavioral risk factors. Brain One ran the paper through its AI to generate editorial and a free downloadable protocol based on it.

  • Paper hypothesizes dementia is preventable via modifiable risk factors
  • Some risk factors (like pollution) aren't fully controllable; others are
  • Brain One used AI to turn the paper into editorial and a usable protocol
  • The protocol is available free on the Brain One website
  • Stephens frames starting prevention in your 30s-40s, not your 50s-60s, as ideal

It's based on the hypothesis that dementia is preventable.

Thoryn Stephens · 06:00
#dementia#longevity#research#prevention
Explainer17:00

Bed rotting: the doom-scrolling trend Brain One built a protocol to fight

Stephens describes 'bed rotting,' a trend prevalent among teens and young adults who scroll for hours in bed while watching an unrealistic 'facade' of other people's lives on social media, leading to depression and anxiety. Brain One built a free bed-rotting protocol to help people break the pattern, and both host and guest tie it directly to poor sleep the night before.

  • 'Bed rotting': lying in bed doom-scrolling for extended periods, common in teens/20s
  • Linked to watching an idealized, unrealistic version of other people's lives online
  • Brain One built a free protocol specifically to counter it
  • Both host and guest connect it to poor sleep quality the prior night
  • Framed as a symptom of algorithms optimizing purely for scroll time

There's a term for that, bed rotting... they're watching this facade of humans living their best life and they're just sitting in bed depressed and…

Thoryn Stephens · 17:30
#screen time#mental health#social media#sleep

Story· 7

Story01:00

Thoryn Stephens' full morning routine, from gratitude to skiing

Stephens walks through his structured morning: gratitude or prayer, 20 minutes of meditation, 20-25 minutes of direct sunlight, hydration with a couple liters of water, intermittent fasting broken with a high-protein meal, and (at home in Colorado) 30 minutes on a bio-resonant device called a biocharger before engineering calls or skiing.

  • Gratitude/prayer followed by 20 minutes of meditation
  • 20-25 minutes of direct sunlight depending on location and time of day
  • A couple liters of water plus intermittent fasting broken with high protein
  • 30 minutes on a 'biocharger' bio-resonant device, done concurrently with other tasks
  • Supplements including BPC-157 peptides, adjusted around training cycles

Morning routine is is pretty well structured. It depends if I'm home in Colorado or I'm traveling.

Thoryn Stephens · 01:00
#morning routine#biohacking#meditation#supplements
Story21:00

Meet the 'most connected human on the planet': six neural implants and a robotic arm

Brain One's chief brain futurist, Dr. Galen Buckwalter, a quadriplegic and former E-Harmony chief scientist, has six neural arrays implanted in his brain as part of a Caltech clinical trial with Blackrock Neuro's Utah Array. He can measure his own neural activity and use it to control a robotic arm, and has three literal ports screwed into his skull that connect to the internet.

  • Six neural arrays: five on the neocortex, one on the prefrontal cortex
  • Part of a Caltech clinical trial using Blackrock Neuro's Utah Array chip
  • Can control a robotic arm using measured neural activity
  • Has three skull ports that physically connect to the internet
  • Former chief scientist at E-Harmony before the clinical trial

He is the most connected human on the planet right now.

Thoryn Stephens · 23:00

He has six of these neural arrays on his actual brain tissue measuring and then potentially exciting different areas of the brain.

Thoryn Stephens · 23:00
#brain-computer interface#neurotechnology#Caltech#disability tech
Story07:30

From genome-sequencing bench scientist to triathlete to Brain One founder

Stephens traces his path: molecular biology and drug development work at a startup acquired by Amgen during the early genome-sequencing era, into triathlon and Ironman training where he first used wearable data to optimize performance, then into digital analytics in LA (including early Facebook API data work), and finally back to science two years ago to found Brain One.

  • Started as a bench scientist in biotech during the early genomics era
  • Ironman training taught him to use data (heart rate, nutrition) to avoid 'bonking' mid-race
  • Moved into digital analytics in LA, including early open Facebook API data work
  • Grew uncomfortable seeing behavioral data used to drive addictive consumer behavior
  • Returned to a science-based purpose about two years ago, founding Brain One

Why are we doing this to have people buy more things they don't need? Why don't we use it for, you know, ultimately optimization of…

Thoryn Stephens · 17:00
#origin story#biotech#triathlon#career pivot
Story30:00

Why Brain One almost dropped the word 'protocol' (and Huberman named a book that anyway)

An advisor suggested Stephens' team drop the word 'protocol' as too intimidating in favor of 'routine.' The very next day, Andrew Huberman announced his new book, titled 'Protocols,' which Stephens takes as validation that the underlying concept resonates regardless of the label used.

  • Advisor Ross Nash suggested 'routine' tests better than 'protocol' with general audiences
  • The next day, Huberman announced a forthcoming book called 'Protocols'
  • Stephens' takeaway: the label matters less than consistent execution
  • Host notes he always asks guests about their 'morning routine,' never 'protocol'

It doesn't matter what you call it as long as you do it, you know.

Thoryn Stephens · 32:00
#branding#language#Huberman#behavior change
Story23:00

The punk song where a quadriplegic scientist sings and controls a synthesizer with his brain

Stephens, also a musician, is releasing a punk track with Dr. Galen Buckwalter, incorporating Buckwalter's actual neural activity data from his Caltech clinical trial. Buckwalter sings on the track while simultaneously controlling a synthesizer using his brain implants, expected to hit Spotify within about a month of recording.

  • Stephens co-writes and produces music alongside his science work
  • Track features Dr. Galen Buckwalter's real neural activity data from his clinical trial
  • Buckwalter sings while controlling a synthesizer with his brain implants in real time
  • Framed as evidence the biology-machine intersection is happening now, not in the future
  • Expected release on Spotify within roughly a month of the interview

We actually wrote a punk song together... where Galen is singing to the track literally and then essentially controlling a synthesizer with his brain at…

Thoryn Stephens · 23:30
#music#brain-computer interface#creativity#Galen Buckwalter
Story45:30

Stephens on visibly reversing his own biological age at 46

Stephens describes a personal transformation over the past year: 30-40 pounds lighter, biomarkers trending younger, and visibly different skin and hair, which he attributes to consistently following his own protocols. He frames it less as chasing lifespan and more as chasing health span, referencing Peter Attia's framing.

  • Lost roughly 30-40 pounds over about a year
  • Says his tracked biomarkers are trending toward a younger biological age
  • Attributes the change to consistent protocol adoption, not a single intervention
  • Explicitly favors Peter Attia's 'health span' framing over raw lifespan
  • Describes himself as the 'most ripped' he's ever been at 46

I am reducing, I'm reversing my age.

Thoryn Stephens · 45:30

I don't necessarily want to live forever, but I want to live the best life I can every single day possible.

Thoryn Stephens · 45:30
#longevity#biological age#health span#transformation
Story43:30

Taking the family dog for hydrogen cloud and bio-resonant treatment after surgery

Stephens shares an anecdote about bringing his mother for a hydrogen cloud treatment at a Four Seasons in Westlake Village, and separately taking the family dog, recovering from a splenectomy, into the same hydrogen cloud plus bio-resonant treatment, which he says helped her recovery. He's candid that the science behind some of these fringe modalities is still mixed.

  • Took his mother for a hydrogen cloud treatment at a Four Seasons practitioner
  • The family dog, recovering from a splenectomy, also received hydrogen cloud plus bio-resonant treatment
  • Stephens is candid that evidence for some of these modalities is 'mixed' and 'woo-woo'
  • Frames Brain One's role as helping validate or invalidate fringe treatments over time
  • Ties into his broader stance of being an early adopter of new modalities

Does it work? Well, the science and some of this stuff is a little bit mixed and a little bit woo-woo.

Thoryn Stephens · 44:00
#alternative medicine#family#biohacking#early adoption

Tool· 1

Tool32:30

Sleep score and resting heart rate: the two metrics Stephens actually watches

Stephens explains why resting heart rate during sleep and next-morning sleep score are his key feedback metrics, and how the timing of your last meal directly drives resting heart rate overnight via digestion. He also flags magnesium (not melatonin) as his preferred sleep supplement.

  • Resting heart rate while sleeping is a key metric alongside HRV (parasympathetic marker)
  • Fasting roughly 8 hours before the last meal lowers resting heart rate overnight
  • Eating close to bedtime (e.g. late sushi) visibly spikes overnight heart rate on wearables
  • Prefers magnesium over melatonin for sleep support
  • Shares sleep scores socially with friends as informal accountability

If you fast 8 hours before your last meal, your resting heart rate will plummet.

Thoryn Stephens · 34:00
#sleep#heart rate#wearables#supplements